A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesis

L-carnitine is important for the catabolism of long-chain fatty acids in the mitochondria. We investigated how the triacylglycerol (TAG)-lowering drug 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA) influenced lipid metabolism in carnitine-depleted, 3-(2,2,2-trimethylhydrazinium)propionate dehyd...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lindquist, Carine, Bjørndal, Bodil, Rossmann, Christine Renate, Svardal, Asbjørn, Hallström, Seth, Berge, Rolf Kristian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874065/
https://ncbi.nlm.nih.gov/pubmed/29590220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194978
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