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Manipulating protein-protein interactions in NRPS type II PCPs

In an effort to elucidate and engineer interactions in type II nonribosomal peptide synthetases, we analyzed biomolecular recognition between the essential peptidyl carrier proteins and adenylation domains using NMR spectroscopy, molecular dynamics, and mutational studies. Three peptidyl carrier pro...

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Dades bibliogràfiques
Publicat a:Biochemistry
Autors principals: Jaremko, Matt J., Lee, D. John, Patel, Ashay, Winslow, Victoria, Opella, Stanley J., McCammon, J. Andrew, Burkart, Michael D.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873958/
https://ncbi.nlm.nih.gov/pubmed/28920687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00884
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