Epithelial-mesenchymal transition leads to NK cell–mediated metastasis-specific immunosurveillance in lung cancer

During epithelial-mesenchymal transition (EMT) epithelial cancer cells transdifferentiate into highly motile, invasive, mesenchymal-like cells, giving rise to disseminating tumor cells. Few of these disseminated cells successfully metastasize. Immune cells and inflammation in the tumor microenvironm...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Chockley, Peter J., Chen, Jun, Chen, Guoan, Beer, David G., Standiford, Theodore J., Keshamouni, Venkateshwar G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873856/
https://ncbi.nlm.nih.gov/pubmed/29324443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97611
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