Peroxisome Proliferator Activated Receptor-γ Activation Inhibits Tumor Metastasis by Antagonizing Smad3 Mediated Epithelial Mesenchymal Transition

Epithelial-mesenchymal transition (EMT) was shown to confer tumor cells with abilities essential for metastasis, including migratory phenotype, invasiveness, and resistance to apoptosis, evading immune surveillance and tumor stem cell traits. Therefore, inhibition of EMT can be an important therapeu...

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Detalhes bibliográficos
Main Authors: Reka, Ajaya Kumar, Kurapati, Himabindu, Narala, Venkata R, Bommer, Guido, Chen, Jun, Standiford, Theodore J., Keshamouni, Venkateshwar G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044476/
https://ncbi.nlm.nih.gov/pubmed/21159608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0570
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