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Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia
Chuvash polycythemia is an inherited disease caused by a homozygous germline VHL(R200W) mutation, which leads to impaired degradation of HIF2α, elevated levels of serum erythropoietin, and erythrocytosis/polycythemia. This phenotype is recapitulated by a mouse model bearing a homozygous Vhl(R200W) m...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5873849/ https://ncbi.nlm.nih.gov/pubmed/29480820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97684 |
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