Human disease-causing NOG missense mutations: Effects on noggin secretion, dimer formation, and bone morphogenetic protein binding

Secreted noggin protein regulates bone morphogenetic protein activity during development. In mice, a complete loss of noggin protein leads to multiple malformations including joint fusion, whereas mice heterozygous for Nog loss-of-function mutations are normal. In humans, heterozygous NOG missense m...

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Bibliographische Detailangaben
Hauptverfasser: Marcelino, Jose, Sciortino, Christopher M., Romero, Michael F., Ulatowski, Lynn M., Ballock, R. Tracy, Economides, Aris N., Eimon, Peter M., Harland, Richard M., Warman, Matthew L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC58733/
https://ncbi.nlm.nih.gov/pubmed/11562478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.201367598
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