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Structural basis and energy landscape for the Ca(2+) gating and calmodulation of the Kv7.2 K(+) channel
The Kv7.2 (KCNQ2) channel is the principal molecular component of the slow voltage-gated, noninactivating K(+) M-current, a key controller of neuronal excitability. To investigate the calmodulin (CaM)-mediated Ca(2+) gating of the channel, we used NMR spectroscopy to structurally and dynamically des...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5873240/ https://ncbi.nlm.nih.gov/pubmed/29463698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800235115 |
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