Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion

A chronic viral or tumor microenvironment can push T cells to exhaustion by promoting coinhibitory ligand expression. However, how host factors control coinhibitory ligand expression and whether viral infection breaks this control during tumor progress is unknown. Here we show a close negative corre...

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Publicado en:Nat Commun
Main Authors: Sun, Cheng, Lan, Peixiang, Han, Qiuju, Huang, Mei, Zhang, Zhihong, Xu, Geliang, Song, Jiaxi, Wang, Jinyu, Wei, Haiming, Zhang, Jian, Sun, Rui, Zhang, Cai, Tian, Zhigang
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871883/
https://ncbi.nlm.nih.gov/pubmed/29593314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03584-3
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