Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion

A chronic viral or tumor microenvironment can push T cells to exhaustion by promoting coinhibitory ligand expression. However, how host factors control coinhibitory ligand expression and whether viral infection breaks this control during tumor progress is unknown. Here we show a close negative corre...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Sun, Cheng, Lan, Peixiang, Han, Qiuju, Huang, Mei, Zhang, Zhihong, Xu, Geliang, Song, Jiaxi, Wang, Jinyu, Wei, Haiming, Zhang, Jian, Sun, Rui, Zhang, Cai, Tian, Zhigang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871883/
https://ncbi.nlm.nih.gov/pubmed/29593314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03584-3
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