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USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells
Gain-of-function p53 mutants such as p53-R175H form stable aggregates that accumulate in cells and play important roles in cancer progression. Selective degradation of gain-of-function p53 mutants has emerged as a highly attractive therapeutic strategy to target cancer cells harboring specific p53 m...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5871815/ https://ncbi.nlm.nih.gov/pubmed/29593334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03599-w |
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