A vicious loop of fatty acid-binding protein 4 and DNA methyltransferase 1 promotes acute myeloid leukemia and acts as a therapeutic target

Aberrant DNA methylation mediated by deregulation of DNA methyltransferases (DNMT) is a key hallmark of acute myeloid leukemia (AML), yet efforts to target DNMT deregulation for drug development have lagged. We previously demonstrated that upregulation of fatty acid-binding protein 4 (FABP4) promote...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Yan, F, Shen, N, Pang, JX, Zhao, N, Zhang, YW, Bode, AM, Al-Kali, A, Litzow, MR, Li, B, Liu, SJ
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871544/
https://ncbi.nlm.nih.gov/pubmed/28993705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.307
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