11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation

Chronically elevated glucocorticoid levels impair cognition and are pro-inflammatory in the brain. Deficiency or inhibition of 11β-hydroxysteroid dehydrogenase type-1 (11β-HSD1), which converts inactive into active glucocorticoids, protects against glucocorticoid-associated chronic stress- or age-re...

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Udgivet i:Brain Behav Immun
Main Authors: Verma, Manu, Kipari, Tiina M.J., Zhang, Zhenguang, Man, Tak Yung, Forster, Thorsten, Homer, Natalie Z.M., Seckl, Jonathan R., Holmes, Megan C., Chapman, Karen E.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871395/
https://ncbi.nlm.nih.gov/pubmed/29162555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2017.11.015
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