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Epigenetic regulation of cell fate reprogramming in aging and disease: A predictive computational model

Understanding the control of epigenetic regulation is key to explain and modify the aging process. Because histone-modifying enzymes are sensitive to shifts in availability of cofactors (e.g. metabolites), cellular epigenetic states may be tied to changing conditions associated with cofactor variabi...

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Veröffentlicht in:PLoS Comput Biol
Hauptverfasser: Folguera-Blasco, Núria, Cuyàs, Elisabet, Menéndez, Javier A., Alarcón, Tomás
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871006/
https://ncbi.nlm.nih.gov/pubmed/29543808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006052
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