cGAS surveillance of micronuclei links genome instability to innate immunity

DNA is strictly compartmentalised within the nucleus to prevent autoimmunity1; despite this cGAS, a cytosolic sensor of dsDNA, is activated in autoinflammatory disorders and by DNA damage2–6. Precisely how cellular DNA gains access to the cytoplasm remains to be determined. Here, we report that cGAS...

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Pubblicato in:Nature
Autori principali: Mackenzie, Karen J., Carroll, Paula, Martin, Carol-Anne, Murina, Olga, Fluteau, Adeline, Simpson, Daniel, Olova, Nelly, Sutcliffe, Hannah, Rainger, Jacqueline, Robertson, Andrea, Osborn, Ruby, Wheeler, Ann, Nowotny, Marcin, Gilbert, Nick, Chandra, Tamir, Reijns, Martin A. M., Jackson, Andrew P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870830/
https://ncbi.nlm.nih.gov/pubmed/28738408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23449
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