TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation

OBJECTIVE: Diabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family. In this study, we use Trpc1/4/5/6(−/−) compound knockout mice to analyze the contribution...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Metab
Prif Awduron: Sachdeva, Robin, Schlotterer, Andrea, Schumacher, Dagmar, Matka, Christin, Mathar, Ilka, Dietrich, Nadine, Medert, Rebekka, Kriebs, Ulrich, Lin, Jihong, Nawroth, Peter, Birnbaumer, Lutz, Fleming, Thomas, Hammes, Hans-Peter, Freichel, Marc
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2018
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870093/
https://ncbi.nlm.nih.gov/pubmed/29373286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.01.003
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