TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation

OBJECTIVE: Diabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family. In this study, we use Trpc1/4/5/6(−/−) compound knockout mice to analyze the contribution...

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Dades bibliogràfiques
Publicat a:Mol Metab
Autors principals: Sachdeva, Robin, Schlotterer, Andrea, Schumacher, Dagmar, Matka, Christin, Mathar, Ilka, Dietrich, Nadine, Medert, Rebekka, Kriebs, Ulrich, Lin, Jihong, Nawroth, Peter, Birnbaumer, Lutz, Fleming, Thomas, Hammes, Hans-Peter, Freichel, Marc
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870093/
https://ncbi.nlm.nih.gov/pubmed/29373286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.01.003
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