TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation

OBJECTIVE: Diabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family. In this study, we use Trpc1/4/5/6(−/−) compound knockout mice to analyze the contribution...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Sachdeva, Robin, Schlotterer, Andrea, Schumacher, Dagmar, Matka, Christin, Mathar, Ilka, Dietrich, Nadine, Medert, Rebekka, Kriebs, Ulrich, Lin, Jihong, Nawroth, Peter, Birnbaumer, Lutz, Fleming, Thomas, Hammes, Hans-Peter, Freichel, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870093/
https://ncbi.nlm.nih.gov/pubmed/29373286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.01.003
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