The D2 Dopamine Receptor Interferes With the Protective Effect of the A(2A) Adenosine Receptor on TDP-43 Mislocalization in Experimental Models of Motor Neuron Degeneration

The A(2A) adenosine receptor (A(2A)R) and D2 dopamine receptor (D(2)R) are two G-protein-coupled receptors that can form dimers and negatively regulate their partners. TAR DNA-binding protein (TDP-43) is a nuclear protein that has been implicated in amyotrophic lateral sclerosis (ALS). Mislocalizati...

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Pubblicato in:Front Neurosci
Autori principali: Lai, Chia-You, Liu, Yu-Ju, Lai, Hsing-Lin, Chen, Hui-Mei, Kuo, Hung-Chi, Liao, Yu-Ping, Chern, Yijuang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869924/
https://ncbi.nlm.nih.gov/pubmed/29615863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00187
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