Effect of alisertib, an investigational aurora a kinase inhibitor on the QTc interval in patients with advanced malignancies

Aims A primary objective of this study was to investigate the effect of single and multiple doses of alisertib, an investigational Aurora A kinase inhibitor, on the QTc interval in patients with advanced malignancies. The dose regimen used was the maximum tolerated dose which was also the recommende...

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Bibliografiske detaljer
Udgivet i:Invest New Drugs
Main Authors: Zhou, Xiaofei, Nemunaitis, John, Pant, Shubham, Bauer, Todd M., Patel, Manish, Sarantopoulos, John, Craig Lockhart, A., Goodman, Daniel, Huebner, Dirk, Mould, Diane R., Venkatakrishnan, Karthik
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2017
Fag:
Phase I Studies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869873/
https://ncbi.nlm.nih.gov/pubmed/28819760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-017-0498-0
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