Effects of rifampin, itraconazole and esomeprazole on the pharmacokinetics of alisertib, an investigational aurora a kinase inhibitor in patients with advanced malignancies

Aim Two studies investigated the effect of gastric acid reducing agents and strong inducers/inhibitors of CYP3A4 on the pharmacokinetics of alisertib, an investigational Aurora A kinase inhibitor, in patients with advanced malignancies. Methods In Study 1, patients received single doses of alisertib...

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Detalles Bibliográficos
Publicado en:Invest New Drugs
Main Authors: Zhou, Xiaofei, Pant, Shubham, Nemunaitis, John, Craig Lockhart, A., Falchook, Gerald, Bauer, Todd M., Patel, Manish, Sarantopoulos, John, Bargfrede, Michael, Muehler, Andreas, Rangachari, Lakshmi, Zhang, Bin, Venkatakrishnan, Karthik
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2017
Assuntos:
Phase I Studies
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869871/
https://ncbi.nlm.nih.gov/pubmed/28852909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-017-0499-z
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