Inhibiting the Plasmodium eIF2α kinase PK4 prevents artemisinin-induced latency

Artemisinin and its derivatives (ARTs) are frontline antimalarial drugs. However, ART monotherapy is associated with a high frequency of recrudescent infection, resulting in treatment failure. A subset of parasites is thought to undergo ART-induced latency, but the mechanisms remain unknown. Here we...

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Publicado no:Cell Host Microbe
Main Authors: Zhang, Min, Gallego-Delgado, Julio, Fernandez-Arias, Cristina, Waters, Norman C., Rodriguez, Ana, Tsuji, Moriya, Wek, Ronald C., Nussenzweig, Victor, Sullivan, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869688/
https://ncbi.nlm.nih.gov/pubmed/29241041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2017.11.005
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