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Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease

We recently established a mouse model (288–330(+/+)) that developed acute respiratory disease resembling human pathology following infection with a high dose (5 × 10(6) PFU) of mouse-adapted MERS-CoV (icMERSma1). Although this high dose conferred fatal respiratory disease in mice, achieving similar...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Douglas, Madeline G., Kocher, Jacob F., Scobey, Trevor, Baric, Ralph S., Cockrell, Adam S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869108/
https://ncbi.nlm.nih.gov/pubmed/29277291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.12.006
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