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Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease
We recently established a mouse model (288–330(+/+)) that developed acute respiratory disease resembling human pathology following infection with a high dose (5 × 10(6) PFU) of mouse-adapted MERS-CoV (icMERSma1). Although this high dose conferred fatal respiratory disease in mice, achieving similar...
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| Udgivet i: | Virology |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier Inc.
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5869108/ https://ncbi.nlm.nih.gov/pubmed/29277291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.12.006 |
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