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Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation

Codon usage biases are found in all genomes and influence protein expression levels. The codon usage effect on protein expression was thought to be mainly due to its impact on translation. Here, we show that transcription termination is an important driving force for codon usage bias in eukaryotes....

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Publicat a:eLife
Autors principals: Zhou, Zhipeng, Dang, Yunkun, Zhou, Mian, Yuan, Haiyan, Liu, Yi
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869017/
https://ncbi.nlm.nih.gov/pubmed/29547124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33569
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