Mechanical strain regulates the Hippo pathway in Drosophila

Animal cells are thought to sense mechanical forces via the transcriptional co-activators YAP (or YAP1) and TAZ (or WWTR1), the sole Drosophila homolog of which is named Yorkie (Yki). In mammalian cells in culture, artificial mechanical forces induce nuclear translocation of YAP and TAZ. Here, we sh...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Fletcher, Georgina C., Diaz-de-la-Loza, Maria-del-Carmen, Borreguero-Muñoz, Nerea, Holder, Maxine, Aguilar-Aragon, Mario, Thompson, Barry J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868995/
https://ncbi.nlm.nih.gov/pubmed/29440303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.159467
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