Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells

BACKGROUND: Hepatocellular carcinoma (HCC) has an increasing incidence and high mortality. Surgical operation is not a comprehensive strategy for liver cancer. Moreover, tolerating systemic chemotherapy is difficult for patients with HCC because hepatic function is often impaired due to underlying c...

Full description

Saved in:
Bibliographic Details
Published in:Onco Targets Ther
Main Authors: Chen, Yu-Chia, Chen, I-shu, Huang, Guan-Jin, Kang, Chi-hsiang, Wang, Kuo-Chiang, Tsao, Min-Jen, Pan, Hung-Wei
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2018
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868578/
https://ncbi.nlm.nih.gov/pubmed/29606879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S147453
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items