The arrestin-1 finger loop interacts with two distinct conformations of active rhodopsin

Signaling of the prototypical G protein–coupled receptor (GPCR) rhodopsin through its cognate G protein transducin (G(t)) is quenched when arrestin binds to the activated receptor. Although the overall architecture of the rhodopsin/arrestin complex is known, many questions regarding its specificity...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Elgeti, Matthias, Kazmin, Roman, Rose, Alexander S., Szczepek, Michal, Hildebrand, Peter W., Bartl, Franz J., Scheerer, Patrick, Hofmann, Klaus Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868258/
https://ncbi.nlm.nih.gov/pubmed/29363577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.817890
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