Crystal structure of a common GPCR-binding interface for G protein and arrestin

G-protein-coupled receptors (GPCRs) transmit extracellular signals to activate intracellular heterotrimeric G proteins (Gαβγ) and arrestins. For G protein signalling, the Gα C-terminus (GαCT) binds to a cytoplasmic crevice of the receptor that opens upon activation. A consensus motif is shared among...

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Detalhes bibliográficos
Main Authors: Szczepek, Michal, Beyrière, Florent, Hofmann, Klaus Peter, Elgeti, Matthias, Kazmin, Roman, Rose, Alexander, Bartl, Franz J., von Stetten, David, Heck, Martin, Sommer, Martha E., Hildebrand, Peter W., Scheerer, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199108/
https://ncbi.nlm.nih.gov/pubmed/25205354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5801
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