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Reduced membrane cholesterol after chronic hypoxia limits Orai1-mediated pulmonary endothelial Ca(2+) entry
Endothelial dysfunction in chronic hypoxia (CH)-induced pulmonary hypertension is characterized by reduced store-operated Ca(2+) entry (SOCE) and diminished Ca(2+)-dependent production of endothelium-derived vasodilators. We recently reported that SOCE in pulmonary arterial endothelial cells (PAECs)...
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| Publicado no: | Am J Physiol Heart Circ Physiol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5867657/ https://ncbi.nlm.nih.gov/pubmed/29101179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00540.2017 |
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