Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs

Herein, we reported on the synthesis of cpIPP, which is a new structurally-reduced analogue of cyclic ADP-ribose (cADPR), a potent Ca(2+)-releasing secondary messenger that was firstly isolated from sea urchin eggs extracts. To obtain cpIPP the “northern” ribose of cADPR was replaced by a pentyl cha...

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Detalhes bibliográficos
Publicado no:Mar Drugs
Main Authors: D’Errico, Stefano, Borbone, Nicola, Catalanotti, Bruno, Secondo, Agnese, Petrozziello, Tiziana, Piccialli, Ilaria, Pannaccione, Anna, Costantino, Valeria, Mayol, Luciano, Piccialli, Gennaro, Oliviero, Giorgia
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5867633/
https://ncbi.nlm.nih.gov/pubmed/29534435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md16030089
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