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CTLA-4Ig (abatacept) balances bone anabolic-effects of T cells and Wnt-10b with anti-anabolic effects of osteoblastic sclerostin
Activated lymphocytes promote inflammation and bone destruction in rheumatoid arthritis, making T cells and B-cells therapeutic targets. Indeed, pharmacological blockade of CD28-costimulation using CTLA-4Ig (abatacept), approved for amelioration of rheumatoid arthritis, renders T cells dormant (aner...
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| Publicado no: | Ann N Y Acad Sci |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5867252/ https://ncbi.nlm.nih.gov/pubmed/29500936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.13643 |
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