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Prediction of metabolism-induced hepatotoxicity on three-dimensional hepatic cell culture and enzyme microarrays
Human liver contains various oxidative and conjugative enzymes that can convert nontoxic parent compounds to toxic metabolites or, conversely, toxic parent compounds to nontoxic metabolites. Unlike primary hepatocytes, which contain myriad drug-metabolizing enzymes (DMEs) but are difficult to cultur...
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| Publicado no: | Arch Toxicol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5867211/ https://ncbi.nlm.nih.gov/pubmed/29167929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2126-3 |
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