Prediction of metabolism-induced hepatotoxicity on three-dimensional hepatic cell culture and enzyme microarrays

Human liver contains various oxidative and conjugative enzymes that can convert nontoxic parent compounds to toxic metabolites or, conversely, toxic parent compounds to nontoxic metabolites. Unlike primary hepatocytes, which contain myriad drug-metabolizing enzymes (DMEs) but are difficult to cultur...

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Veröffentlicht in:Arch Toxicol
Hauptverfasser: Yu, Kyeong-Nam, Nadanaciva, Sashi, Rana, Payal, Lee, Dong Woo, Ku, Bosung, Roth, Alexander D., Dordick, Jonathan S., Will, Yvonne, Lee, Moo-Yeal
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5867211/
https://ncbi.nlm.nih.gov/pubmed/29167929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2126-3
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