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SV40 intron, a potent strong intron element that effectively increases transgene expression in transfected Chinese hamster ovary cells

Chinese hamster ovary (CHO) cells have become the most widely utilized mammalian cell line for the production of recombinant proteins. However, the product yield and transgene instability need to be further increased and solved. In this study, we investigated the effect of five different introns on...

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Bibliografski detalji
Izdano u:J Cell Mol Med
Glavni autori: Xu, Dan‐hua, Wang, Xiao‐yin, Jia, Yan‐long, Wang, Tian‐yun, Tian, Zheng‐wei, Feng, Xin, Zhang, Yin‐na
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5867124/
https://ncbi.nlm.nih.gov/pubmed/29441681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13504
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