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The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes
Tamoxifen, a standard therapy for breast cancer, is metabolized to compounds with anti-estrogenic as well as estrogen-like action at the estrogen receptor. Little is known about the formation of estrogen-like metabolites and their biological impact. Thus, we characterized the estrogen-like metabolit...
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| Publicado no: | Arch Toxicol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5866846/ https://ncbi.nlm.nih.gov/pubmed/29285606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2147-y |
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