Placentation defects are highly prevalent in embryonic lethal mouse mutants

Large-scale phenotyping efforts have demonstrated that approximately 25-30% of mouse gene knockouts cause intra-uterine lethality. Analysis of these mutants has largely focussed on the embryo but not the placenta, despite the critical role of this extra-embryonic organ for developmental progression....

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Bibliografische gegevens
Gepubliceerd in:Nature
Hoofdauteurs: Perez-Garcia, Vicente, Fineberg, Elena, Wilson, Robert, Murray, Alexander, Mazzeo, Cecilia Icoresi, Tudor, Catherine, Sienerth, Arnold, White, Jacqueline K., Tuck, Elizabeth, Ryder, Edward J., Gleeson, Diane, Siragher, Emma, Wardle-Jones, Hannah, Staudt, Nicole, Wali, Neha, Collins, John, Geyer, Stefan, Busch-Nentwich, Elisabeth M., Galli, Antonella, Smith, James C., Robertson, Elizabeth, Adams, David J., Weninger, Wolfgang J., Mohun, Timothy, Hemberger, Myriam
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866719/
https://ncbi.nlm.nih.gov/pubmed/29539633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature26002
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