Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice [version 1; referees: 1 approved, 2 approved with reservations]

Background: Identifying genes that are essential for mouse embryonic development and survival through term is a powerful and unbiased way to discover possible genetic determinants of human developmental disorders. Characterising the changes in mouse embryos that result from ablation of lethal genes...

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Bibliographische Detailangaben
Hauptverfasser: Robert Wilson, Stefan H. Geyer, Lukas Reissig, Julia Rose, Dorota Szumska, Emily Hardman, Fabrice Prin, Christina McGuire, Ramiro Ramirez-Solis, Jacqui White, Antonella Galli, Catherine Tudor, Elizabeth Tuck, Cecilia Mazzeo, James C. Smith, Elizabeth Robertson, David J. Adams, Timothy Mohun, Wolfgang J. Weninger
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wellcome 2016-11-01
Schriftenreihe:Wellcome Open Research
Schlagworte:
Animal Genetics
Genomics
Online Zugang:https://wellcomeopenresearch.org/articles/1-1/v1
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