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Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference

Small interfering RNA (siRNA) represents a promising class of inhibitors in both fundamental research and the clinic. Numerous delivery vehicles have been developed to facilitate siRNA delivery. Nevertheless, achieving highly potent RNA interference (RNAi) toward clinical translation requires effici...

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Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Li, Jiahe, Wu, Connie, Wang, Wade, He, Yanpu, Elkayam, Elad, Joshua-Tor, Leemor, Hammond, Paula T.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866582/
https://ncbi.nlm.nih.gov/pubmed/29432194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719565115
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