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Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference

Small interfering RNA (siRNA) represents a promising class of inhibitors in both fundamental research and the clinic. Numerous delivery vehicles have been developed to facilitate siRNA delivery. Nevertheless, achieving highly potent RNA interference (RNAi) toward clinical translation requires effici...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Li, Jiahe, Wu, Connie, Wang, Wade, He, Yanpu, Elkayam, Elad, Joshua-Tor, Leemor, Hammond, Paula T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866582/
https://ncbi.nlm.nih.gov/pubmed/29432194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719565115
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