Src family kinase inhibitors blunt PACAP-induced PAC1 receptor endocytosis, phosphorylation of ERK, and the increase in cardiac neuron excitability

Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors (Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons. This modulation of excitability is mediated in part by plasma membrane G protein-dependent activation of adenylyl cyclase a...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Tompkins, John D., Clason, Todd A., Buttolph, Thomas R., Girard, Beatrice M., Linden, Anne K., Hardwick, Jean C., Merriam, Laura A., May, Victor, Parsons, Rodney L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866440/
https://ncbi.nlm.nih.gov/pubmed/29141923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00223.2017
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