Src family kinase inhibitors blunt PACAP-induced PAC1 receptor endocytosis, phosphorylation of ERK, and the increase in cardiac neuron excitability

Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors (Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons. This modulation of excitability is mediated in part by plasma membrane G protein-dependent activation of adenylyl cyclase a...

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Publicat a:Am J Physiol Cell Physiol
Autors principals: Tompkins, John D., Clason, Todd A., Buttolph, Thomas R., Girard, Beatrice M., Linden, Anne K., Hardwick, Jean C., Merriam, Laura A., May, Victor, Parsons, Rodney L.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866440/
https://ncbi.nlm.nih.gov/pubmed/29141923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00223.2017
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