Src family kinase inhibitors blunt PACAP-induced PAC1 receptor endocytosis, phosphorylation of ERK, and the increase in cardiac neuron excitability

Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors (Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons. This modulation of excitability is mediated in part by plasma membrane G protein-dependent activation of adenylyl cyclase a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Physiol Cell Physiol
Prif Awduron: Tompkins, John D., Clason, Todd A., Buttolph, Thomas R., Girard, Beatrice M., Linden, Anne K., Hardwick, Jean C., Merriam, Laura A., May, Victor, Parsons, Rodney L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866440/
https://ncbi.nlm.nih.gov/pubmed/29141923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00223.2017
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