Calcium influx, but not intracellular calcium release, supports PACAP-mediated ERK activation in HEK PAC1 receptor cells

In HEK cells expressing GFP-tagged PAC1Hop1 receptors, PACAP augments ERK phosphorylation through two parallel pathways; one through PACAP/PAC1 receptor internalization/endosome MEK/ERK signaling, the other through PLC/DAG/PKC activation. We examined whether elevation of intracellular calcium ([Ca(2...

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Bibliographic Details
Main Authors: May, Victor, Clason, Todd A., Buttolph, Thomas R., Girard, Beatrice M., Parsons, Rodney L.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194181/
https://ncbi.nlm.nih.gov/pubmed/24723666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-014-0300-0
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