Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

The incidence of cutaneous squamous cell carcinoma (cSCC) is rising. Whilst the majority are cured surgically, aggressive metastatic cSCC carry a poor prognosis. Inactivating mutations in transforming growth factor beta (TGF-β) receptors have been identified amongst genetic drivers of sporadic tumou...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Rose, Aidan M., Spender, Lindsay C., Stephen, Christopher, Mitchell, Alastair, Rickaby, William, Bray, Susan, Evans, Alan T., Dayal, Jasbani, Purdie, Karin J., Harwood, Catherine A., Proby, Charlotte M., Leigh, Irene M., Coates, Philip J., Inman, Gareth J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865689/
https://ncbi.nlm.nih.gov/pubmed/29581863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24545
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