The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Cutaneous squamous cell carcinoma (cSCC) has a high tumour mutational burden (50 mutations per megabase DNA pair). Here, we combine whole-exome analyses from 40 primary cSCC tumours, comprising 20 well-differentiated and 20 moderately/poorly differentiated tumours, with accompanying clinical data fr...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Inman, Gareth J., Wang, Jun, Nagano, Ai, Alexandrov, Ludmil B., Purdie, Karin J., Taylor, Richard G., Sherwood, Victoria, Thomson, Jason, Hogan, Sarah, Spender, Lindsay C., South, Andrew P., Stratton, Michael, Chelala, Claude, Harwood, Catherine A., Proby, Charlotte M., Leigh, Irene M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131170/
https://ncbi.nlm.nih.gov/pubmed/30202019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06027-1
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky