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Hsp90 inhibitor NMS-E973 exerts the anticancer effect against glioblastoma via induction of PUMA-mediated apoptosis

BACKGROUND: Glioblastoma is one of the most aggressive and common malignancies of the central nervous system in humans. Owing to the correlation of high Hsp90 expression with prognosis and clinical pathology features of diverse types of cancer, targeting Hsp90 with small-molecule inhibitors has beco...

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Bibliografske podrobnosti
izdano v:Onco Targets Ther
Main Authors: Sun, Libo, Yang, Shoujun, Chi, Guonan, Jin, Xingyi
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865573/
https://ncbi.nlm.nih.gov/pubmed/29593424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S160813
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