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High-Dose Deferoxamine Treatment Disrupts Intracellular Iron Homeostasis, Reduces Growth, and Induces Apoptosis in Metastatic and Nonmetastatic Breast Cancer Cell Lines

Mounting evidence suggest that iron overload enhances cancer growth and metastasis; hence, iron chelation is being increasingly used as part of the treatment regimen in patients with cancer. Now whether iron chelation depletes intracellular iron and/or disrupts intracellular iron homeostasis is yet...

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Bibliografiske detaljer
Udgivet i:Technol Cancer Res Treat
Main Authors: Bajbouj, Khuloud, Shafarin, Jasmin, Hamad, Mawieh
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865460/
https://ncbi.nlm.nih.gov/pubmed/29562821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1533033818764470
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