Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10

Toll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of TLR10. Recognition of dsRNA by TLR10 activates rec...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lee, Suki Man-Yan, Yip, Tsz-Fung, Yan, Sheng, Jin, Dong-Yan, Wei, Hong-Li, Guo, Rey-Ting, Peiris, Joseph Sriyal Malik
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865411/
https://ncbi.nlm.nih.gov/pubmed/29616030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00516
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