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Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10
Toll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of TLR10. Recognition of dsRNA by TLR10 activates rec...
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| Izdano u: | Front Immunol |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5865411/ https://ncbi.nlm.nih.gov/pubmed/29616030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00516 |
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