Mechanisms of Triptolide-Induced Hepatotoxicity and Protective Effect of Combined Use of Isoliquiritigenin: Possible Roles of Nrf2 and Hepatic Transporters

Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquiritigenin (ISL) has been reported to be able to protect against TP-induced liver injury, but the mechanisms are not fully elucidated. This study aims to explore the role of nuclea...

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Bibliografski detalji
Izdano u:Front Pharmacol
Glavni autori: Hou, Zhenyan, Chen, Lei, Fang, Pingfei, Cai, Hualin, Tang, Huaibo, Peng, Yongbo, Deng, Yang, Cao, Lingjuan, Li, Huande, Zhang, Bikui, Yan, Miao
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Pharmacology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865274/
https://ncbi.nlm.nih.gov/pubmed/29615906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00226
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