Mechanisms of Triptolide-Induced Hepatotoxicity and Protective Effect of Combined Use of Isoliquiritigenin: Possible Roles of Nrf2 and Hepatic Transporters

Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquiritigenin (ISL) has been reported to be able to protect against TP-induced liver injury, but the mechanisms are not fully elucidated. This study aims to explore the role of nuclea...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Hou, Zhenyan, Chen, Lei, Fang, Pingfei, Cai, Hualin, Tang, Huaibo, Peng, Yongbo, Deng, Yang, Cao, Lingjuan, Li, Huande, Zhang, Bikui, Yan, Miao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865274/
https://ncbi.nlm.nih.gov/pubmed/29615906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00226
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