Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

Lactate exchange between glycolytic and oxidative cancer cells is proposed to optimize tumor growth. Blocking lactate uptake through monocarboxylate transporter 1 (MCT1) represents an attractive therapeutic strategy but may stimulate glucose consumption by oxidative cancer cells. We report here that...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Corbet, Cyril, Bastien, Estelle, Draoui, Nihed, Doix, Bastien, Mignion, Lionel, Jordan, Bénédicte F., Marchand, Arnaud, Vanherck, Jean-Christophe, Chaltin, Patrick, Schakman, Olivier, Becker, Holger M., Riant, Olivier, Feron, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865202/
https://ncbi.nlm.nih.gov/pubmed/29572438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03525-0
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