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Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments
Hypoxia and oncogene expression both stimulate glycolytic metabolism in tumors, thereby leading to lactate production. However, lactate is more than merely a by-product of glycolysis: it can be used as a metabolic fuel by oxidative cancer cells. This phenomenon resembles processes that have been des...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Limited
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3209642/ https://ncbi.nlm.nih.gov/pubmed/22065843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.007724 |
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