Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

Lactate exchange between glycolytic and oxidative cancer cells is proposed to optimize tumor growth. Blocking lactate uptake through monocarboxylate transporter 1 (MCT1) represents an attractive therapeutic strategy but may stimulate glucose consumption by oxidative cancer cells. We report here that...

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Udgivet i:Nat Commun
Main Authors: Corbet, Cyril, Bastien, Estelle, Draoui, Nihed, Doix, Bastien, Mignion, Lionel, Jordan, Bénédicte F., Marchand, Arnaud, Vanherck, Jean-Christophe, Chaltin, Patrick, Schakman, Olivier, Becker, Holger M., Riant, Olivier, Feron, Olivier
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865202/
https://ncbi.nlm.nih.gov/pubmed/29572438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03525-0
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